Evidence-based Health Care Special Lecture I

[http://minato.sip21c.org/ebhc.html] Latest update: 19 July 2017 (Wed)

Archives: 2016, 2015, 2014, 2013, 2012

1. Aims of the lecture

For properly conducting health related research, basic knowledge of research design and statistics will be given.

In principle, the lecture is done in Japanese. Foreign students may ask the lecturer individually if necessary.

The text written in Japaneses [pdf format], latest version is on 26th July 2016 is freely available (Comments are welcome).

Caution! There is no lecture on June 7 and July 5. In addition, lectures by Assoc. Prof. Komai and guest lecturer Dr. Sumida will be given as an intensive course later. Please check the notice board in the Myodani campus.

2. Program

The very basics of health research (Apr 12, handout in Japanese)
Basic terms in health/epidemiologic research (Apr 19, presentation, exercise)
Sample size issues (Apr 26, presentation in English) (cf. E-learning course on ICRweb is useful.)
Research design (mostly experimental study design) (May 10, handout) [A review paper pdf for crossover design]
Data entry, missing data, graphical check (May 17, Excel format sample data)
Hypothesis testing, SD and SE. Test of the location difference (May 24, handout in English)
Test of proportion difference, Cross tabulation and its analysis (May 31)
ANOVA and Multiple comparison (June 14)
Correlation, Regression and its application: Analysis of Covariance and Logistic Regression (June 21, handout and additional handout (in Japanese))
Repeated measurement: Comparison of location parameters among 3 or more groups with corresponding data / Evaluation of performances of diagnostic testing: ROC, Kappa statistics, and Bland-Altman plot (June 28)
Survival analysis (ref. in Japanese) and the method to summarize systematic review: meta-analysis (July 12)
Example of meta-analysis: Is sperm concentration decreasing over the world?
- The first paper written by Carlsen et al. (1992) in BMJ, which includes the data as table. According to the name of the research leader, so-called "Skakkebaek paper".
- Reanalysis of the data in "Skakkebaek paper" by Swan et al. (1997)
- Re-reanalysis of the data in "Skakkebaek papar" with newly added data by Swan et al. (2000)
- New paper criticizing the "Skakkebaek paper" and followers about sampling bias written by Deonandan and Jaleel (2012)
- My web-log critics on "Skakkebaek paper" in 1998 (in Japanese), which has been later published in "Kagaku" journal by Iwanami-Shoten
- Tab-delimited text file of the data in "Skakkebaek paper"
- The R code to plot the data above as same graph as "Skakkebaek paper"
Mini test (July 19, QuestionsCCSample answerCR code (comments in Japanese))
Geographic information data analysis and spatial epidemiology (July 26, Special Lecture given by Dr. Susumu Tanimura)
The analysis of the data in experiments (1): Analysis of electrophoresis data, given by Assoc. Prof. Koichiro Komai (August 4, 18:30-20:00 at E802)
The analysis of the data in experiments (2): Omics and Genome-data analysis by the Special Lecturer, Dr. Kayo Sumita from Sumitomo-Kagaku (August 5, 10:00-12:00 at E802 or E803)

3. Evaluation

Based on the mini-reports and mini-test.

References

Machin D, Campbell MJ, Walters SJ (2007) Medical Statistics, 4th ed., Wiley
Lang TA, Secic M (2006) How to report statistics in medicine: Annotated guidelines for authors, editors, and reviewers. 2nd ed., American College of Physicians.
Peacock JL, Peacock PJ (2011) Oxford handbook of medical statistics. Oxford Univ. Press
Power and Sample Size (Vanderbilt University)
EZR (Jichi Medical School)
The lecture note for medical statistics at Gunma University written by Minato Nakazawa

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