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Evidence-based Health Care Special Lecture I

[http://minato.sip21c.org/ebhc.html] Latest update: 25 July 2018 (Wed)

Archives: 2017, 2016, 2015, 2014, 2013, 2012

1. Aims of the lecture

For properly conducting health related research, basic knowledge of research design and statistics will be given.

In principle, the lecture is done in Japanese. Foreign students may ask the lecturer individually if necessary.

The text written in Japaneses [pdf format], latest version is on 30th May 2018 is freely available (Comments are welcome).

Caution! There is no lecture on June 13 and July 11. In addition, lectures by Assoc. Prof. Komai and guest lecturer Dr. Sumida will be given as an intensive course later. Please check the notice board in the Myodani campus.

2. Program

1. The very basics of health research (Apr 11, handout in Japanese)
2. Basic terms in health/epidemiologic research (Apr 18, presentation, exercise)
3. Sample size issues (Apr 25, handout in English) (cf. E-learning course on ICRweb is useful.)
4. Research design (mostly experimental study design) (May 2, handout) [A review paper pdf for crossover design]
5. Data entry, missing data, graphical check (May 9, Excel format sample data)
6. Hypothesis testing, SD and SE. Test of the location difference (May 16, handout in English)
7. Test of proportion difference, Cross tabulation and its analysis (May 23, handout)
8. ANOVA and Multiple comparison (May 30, handout)
9. Correlation, Regression and its application: Analysis of Covariance and Logistic Regression (June 6, handout)
10. Repeated measurement: Comparison of location parameters among 3 or more groups with corresponding data, Kappa statistics, McNemar's test (June 20, handout)
11. Evaluation of performances of diagnostic testing: ROC and Bland-Altman plot and the method to summarize systematic review: meta-analysis (June 27, handout for ROC and Bland-Altman plot�Chandout for meta-analysis)
    Example of meta-analysis: Is sperm concentration decreasing over the world?
    • The first paper written by Carlsen et al. (1992) in BMJ, which includes the data as table. According to the name of the research leader, so-called "Skakkebaek paper".
    • Reanalysis of the data in "Skakkebaek paper" by Swan et al. (1997)
    • Re-reanalysis of the data in "Skakkebaek papar" with newly added data by Swan et al. (2000)
    • New paper criticizing the "Skakkebaek paper" and followers about sampling bias written by Deonandan and Jaleel (2012)
    • New review paper (2016)�CNew cross-sectional study in Denmark (2018) by Prof. Skakkebaek's group.
    • New meta-regression paper by Dr. Swan's group (2017) (In addition, the supplementary material explaining the actual process of data collection and analysis is also available. However, downloading the data requires the password, available from the corresponding author.) (Interview to the first author is available) (Comments from professionals)
    • My web-log critics on "Skakkebaek paper" in 1998 (in Japanese), which has been later published in "Kagaku" journal by Iwanami-Shoten
    • Tab-delimited text file of the data in "Skakkebaek paper"
    • The R code to plot the data above as same graph as "Skakkebaek paper"
12. Survival analysis (handout in English�Cref. in Japanese) (July 4)
13. Mini test (July 18, Questions�CSample answer�CR code (comments in Japanese))
14. Geographic information data analysis and spatial epidemiology (July 25, Special Lecture given by Dr. Susumu Tanimura)
15. The analysis of the data in experiments (1): Omics and Genome-data analysis by the Special Lecturer, Dr. Kayo Sumita from Sumitomo-Kagaku (July 28, 10:00-11:30 at E802)
16. The analysis of the data in experiments (2): Analysis of electrophoresis data, given by Assoc. Prof. Koichiro Komai (August 3, 18:30-20:00 at E802)

3. Evaluation

Based on the mini-reports and mini-test.

References

• Machin D, Campbell MJ, Walters SJ (2007) Medical Statistics, 4th ed., Wiley
• Lang TA, Secic M (2006) How to report statistics in medicine: Annotated guidelines for authors, editors, and reviewers. 2nd ed., American College of Physicians.
• Peacock JL, Peacock PJ (2011) Oxford handbook of medical statistics. Oxford Univ. Press
• Power and Sample Size (Vanderbilt University)
• EZR (Jichi Medical School)
• The lecture note for medical statistics at Gunma University written by Minato Nakazawa

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